Cochran’s final chief of staff, Brad White, said Cochran died Thursday.
Cochran was elected to the U.S. House in 1972. When he won a Senate seat in 1978, he became the first Republican since Reconstruction to win statewide office in Mississippi.
He led the Appropriations Committee in 2005-06 and regained the chairmanship in January 2015, when the GOP retook the Senate.
Known for working across party lines, Cochran easily won most of his re-election campaigns. However, he struggled before winning a 2014 Republican primary over a tea party-backed state lawmaker who was received financial support from libertarian-leaning groups that criticized Cochran as a big spender.